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Genengnews.com: Family Genetics Key to Severity of Autism and other Neurodevelopmental Disorders

Genengnews.com: Family Genetics Key to Severity of Autism and other Neurodevelopmental Disorders

Techniques such as high-throughput genome sequencing have allowed scientists to identify hundreds of genetic variants that are linked with increased risk of different neurodevelopmental or neuropsychological disorders, such epilepsy, schizophrenia, intellectual disability, and autism spectrum disorder (ASD). However, two people with the same known risk variant won’t necessarily present with

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Genengnews.com: Autism Social Interaction Difficulties Caused by Poor Synapse Maturation

Genengnews.com: Autism Social Interaction Difficulties Caused by Poor Synapse Maturation

A significant debilitating factor for those afflicted with autism spectral disorders (ASD) is impairment of social communication. Now, a team of investigators from the Universities of Geneva (UNIGE) and Basel (UNIBAS), in Switzerland believe they have uncovered what happens in ASD patients’ brains that disrupts their social skills. Findings from

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Genengnews.com: Autism Risk Linked with Maternal Gut Microbiome during Pregnancy

Genengnews.com: Autism Risk Linked with Maternal Gut Microbiome during Pregnancy

Recent studies have linked autism with immune response dysregulation and altered microbiome composition. “This has led to growing speculation about potential roles for hyperactive immune responses and the microbiome in autism,” the authors write. “Yet how microbiome–immune crosstalk contributes to neurodevelopmental disorders currently remains poorly understood.”

The relationship between

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Genengnews.com: Autism and Mom's Microbiome Could Be Linked

Genengnews.com: Autism and Mom's Microbiome Could Be Linked

Recent studies have linked autism with immune response dysregulation and altered microbiome composition. “This has led to growing speculation about potential roles for hyperactive immune responses and the microbiome in autism,” the authors write. “Yet how microbiome–immune crosstalk contributes to neurodevelopmental disorders currently remains poorly understood.”

The relationship between

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Genengnews.com: Autism Risk Increased through Structural Variants Inherited from Dad

Genengnews.com: Autism Risk Increased through Structural Variants Inherited from Dad

A scientific team led by University of California San Diego School of Medicine researchers says it has identified the cause that may explain why some people develop autism—rare inherited variants in regions of paternal noncoding DNA. Previous studies have demonstrated that de novo mutations contribute to approximately one-third of cases of

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Genengnews.com: Structural Variants Inherited from Dad Linked to Autism Risk

Genengnews.com: Structural Variants Inherited from Dad Linked to Autism Risk

A scientific team led by University of California San Diego School of Medicine researchers says it has identified the cause that may explain why some people develop autism: rare inherited variants in regions of paternal non-coding DNA. Previous studies have demonstrated that de novo mutations contribute to approximately one-third of cases

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Genengnews.com: Autism-Like Social Deficits Reversed by Epigenetic Drug

Genengnews.com: Autism-Like Social Deficits Reversed by Epigenetic Drug

A chromatin-loosening drug already approved as a cancer therapeutic may have another application—reversing the social deficits associated with autism spectrum disorder (ASD). If chromatin is packed too tightly, it can entomb genes, preventing their expression by closing them off from the cell’s transcriptional machinery.

Effectively disinterring genes, and thereby

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Genengnews.com: Blood/Urine Biomarker Tests Developed for Autism Spectrum Disorders

Genengnews.com: Blood/Urine Biomarker Tests Developed for Autism Spectrum Disorders

Scientists at the University of Warwick, U.K., have developed biomarker-based blood and urine tests for autism spectrum disorders (ASD), which they suggest could enable much earlier diagnosis in children, and so speed the start of treatment. The approach, developed by a team headed by Naila Rabbani, Reader of Experimental Systems

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Genengnews.com: New Autism Drug Shows Promise in Preclinical Study

Genengnews.com: New Autism Drug Shows Promise in Preclinical Study

Research concerning autism spectrum disorder (ASD) has seen its fair share of controversy over the years, but as researchers relentlessly pursue the underlying causes of this developmental disorder, scientific consensus and public awareness grow. Adding to the exponential growth of data for ASD, a group of investigators led by researchers

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Genengnews.com: Autism Bias toward Males Explained through Signaling Pathway

Genengnews.com: Autism Bias toward Males Explained through Signaling Pathway

The disproportionate ratio of males affected by autism spectral disorder (ASD) has perplexed researchers for several years. Moreover, this male bias is also seen in other neurodevelopmental disorders, like attention-deficit hyperactivity disorder (ADHD) and specific language impairments. Now, new research by investigators at the University of Iowa Carver College of

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Genengnews.com: Autism Bias toward Males Explained through Signalling Pathway

Genengnews.com: Autism Bias toward Males Explained through Signalling Pathway

The disproportionate ratio of males affected by autism spectral disorder (ASD) has perplexed researchers for several years. Moreover, this male bias is also seen in other neurodevelopmental disorders, like attention-deficit hyperactivity disorder (ADHD) and specific language impairments. Now, new research by investigators at the University of Iowa Carver College of

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Genengnews.com: Autism Protein Epigenetically Missregulated Study Finds, Opening Door for New Treatments

Genengnews.com: Autism Protein Epigenetically Missregulated Study Finds, Opening Door for New Treatments

One such VP is a protein called Brd4, which adjusts the activity of other genes. When researchers engineered mice to lack FMRP, Brd4 was free to monkey with genes’ activity levels. Scientists already have a drug that can curb Brd4’s actions—a small molecule called JQ1 that prevents Brd4

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Genengnews.com: Autism Protein Epigenetically Misregulated Study Finds, Opening Door for New Treatments

Genengnews.com: Autism Protein Epigenetically Misregulated Study Finds, Opening Door for New Treatments

One such VP is a protein called Brd4, which adjusts the activity of other genes. When researchers engineered mice to lack FMRP, Brd4 was free to monkey with genes’ activity levels. Scientists already have a drug that can curb Brd4’s actions—a small molecule called JQ1 that prevents Brd4

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Genengnews.com: Autism Linked to Mitochondrial DNA Variation, Possible Cause Gains Traction

Genengnews.com: Autism Linked to Mitochondrial DNA Variation, Possible Cause Gains Traction

Looking beyond the nuclear genome, researchers have found further evidence that the nearby mitochondrial genome, often overlooked, could be an underlying cause of autism spectrum disorder (ASD). The study reported an association between ancient mitochondrial DNA (mtDNA) variants and ASD and was published August 23 in JAMA Psychiatry.

“What we discovered

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